CD11c+ CD8 T cells cause IFN-γ–dependent autoimmune neuroinflammation that is restrained by PD-1 signaling
Daniel Hwang, Gholamreza Azizi, Larissa Lumi Watanabe Ishikawa, Maryam Seyedsadr, Arin Cox, Soohwa Jang, Ezgi Kasimoglu, Abdolmohamad Rostami, Guang-Xian Zhang, Bogoljub Ciric · 2026
Read CD11c+ CD8 T cells cause IFN-γ–dependent autoimmune neuroinflammation that is restrained by PD-1 signaling by Daniel Hwang, Gholamreza Azizi, Larissa Lumi Watanabe Ishikawa, Maryam Seyedsadr, Arin Cox, Soohwa Jang, Ezgi Kasimoglu, Abdolmohamad Rostami, Guang-Xian Zhang, Bogoljub Ciric (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13232716.txt.
Description
Daniel Hwang and co-authors study a class of killer T cells in a 2026 mouse study tied to multiple sclerosis. In human lesions, these CD8 cells outnumber the better-known CD4 type, yet their role is poorly mapped. Standard mouse models lean on CD4 cells and produce mainly spinal cord harm, unlike the brain-heavy human pattern.
The team built a CD8-driven model with brain-centered swelling, poor balance, and weight loss. Most of the invading cells carried a surface marker that flags the harmful subset. Blocking one signal molecule suppressed the disease, while blocking a brake molecule made it worse. Readers get a model that matches human disease more closely.
Catalog record
| CREATOR | Daniel Hwang, Gholamreza Azizi, Larissa Lumi Watanabe Ishikawa, Maryam Seyedsadr, Arin Cox, Soohwa Jang, Ezgi Kasimoglu, Abdolmohamad Rostami, Guang-Xian Zhang, Bogoljub Ciric |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |