Brain and knee joint degeneration following anterior cruciate ligament injury in a mouse model of Alzheimer’s disease
Wei Yao, Barton L Wise, Yu-Yang Lin, Ming Fan, Shanxiu Xu, I-Shin Ju, Jonathan I Berg, Jill L Silverman, Gabriela G Loots, Blaine A Christiansen · 2026
Read Brain and knee joint degeneration following anterior cruciate ligament injury in a mouse model of Alzheimer’s disease by Wei Yao, Barton L Wise, Yu-Yang Lin, Ming Fan, Shanxiu Xu, I-Shin Ju, Jonathan I Berg, Jill L Silverman, Gabriela G Loots, Blaine A Christiansen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13232624.txt.
Description
Wei Yao and co-authors study joint and brain degeneration in an Alzheimer mouse model in this 2026 paper. Alzheimer disease and osteoarthritis are both common in older people. Human and mouse work hints that joint disease may raise dementia risk. The team injured the knee ligament in mice bred to develop Alzheimer like changes.
Injury was done without surgery at seven months of age. Memory and behavior tests ran six weeks later, including maze and object tasks. Knees, brains, and joint tissue were then checked for degeneration and Alzheimer proteins. Female Alzheimer mice with joint injury showed worse outcomes on several measures. The study probes a two way link between joint damage and brain decline.
Catalog record
| CREATOR | Wei Yao, Barton L Wise, Yu-Yang Lin, Ming Fan, Shanxiu Xu, I-Shin Ju, Jonathan I Berg, Jill L Silverman, Gabriela G Loots, Blaine A Christiansen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |