Monoclonal antibodies targeting PCDH7 inhibit tumor growth and enhance immune responses in KRAS-mutant non–small cell lung cancer
Nicole Novaresi, Poorva Ghosh, Shayna Thomas-Jardin, Hui Deng, Xuejun Fan, Zhiqiang Ku, Wei Xiong, Xiaorong Zhou, Jingfei Zhu, Huiyu Li, Mahesh S. Padanad, Bethany Smith, Chul Ahn, John D. Minna, Zhiqiang An, Ningyan Zhang, Kathryn A. O’Donnell · 2026
Read Monoclonal antibodies targeting PCDH7 inhibit tumor growth and enhance immune responses in KRAS-mutant non–small cell lung cancer by Nicole Novaresi, Poorva Ghosh, Shayna Thomas-Jardin, Hui Deng, Xuejun Fan, Zhiqiang Ku, Wei Xiong, Xiaorong Zhou, Jingfei Zhu, Huiyu Li, Mahesh S. Padanad, Bethany Smith, Chul Ahn, John D. Minna, Zhiqiang An, Ningyan Zhang, Kathryn A. O’Donnell (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13232558.txt.
Description
Nicole Novaresi and colleagues target in 2026 a surface protein that helps KRAS-driven lung cancers grow and hide. The protein PCDH7 appears at high levels in lung adenocarcinoma and tracks with poor outcomes for patients. Removing it in mouse models shrank tumors and extended survival, marking it as a drug target.
Antibodies built against the protein blocked a key growth pathway inside tumor cells and slowed tumors across several models. One lead antibody made tumors respond better to two approved pathway drugs given alongside it. A human-ready version also helped immune cells kill tumor cells directly. Treated tumors drew in more active killer immune cells, which strengthened the overall attack.
Catalog record
| CREATOR | Nicole Novaresi, Poorva Ghosh, Shayna Thomas-Jardin, Hui Deng, Xuejun Fan, Zhiqiang Ku, Wei Xiong, Xiaorong Zhou, Jingfei Zhu, Huiyu Li, Mahesh S. Padanad, Bethany Smith, Chul Ahn, John D. Minna, Zhiqiang An, Ningyan Zhang, Kathryn A. O’Donnell |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |