PARP1 inhibition in naïve mouse embryonic stem cells induces viral mimicry
Jianming Xu, Simon D Schwarz, Kapila Gunasekera, Roland Steinacher, Anna Kuśnierczyk, Michael O Hottiger, Primo Schär · 2026
Read PARP1 inhibition in naïve mouse embryonic stem cells induces viral mimicry by Jianming Xu, Simon D Schwarz, Kapila Gunasekera, Roland Steinacher, Anna Kuśnierczyk, Michael O Hottiger, Primo Schär (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13232494.txt.
Description
Jianming Xu and co-authors show that blocking a DNA repair protein in naive mouse stem cells triggers a response that mimics viral infection, in a 2026 study. Drugs of this class work in cancer by killing cells that cannot repair DNA breaks. The stem cells studied here repair DNA well, yet they proved highly sensitive to the drugs.
The response runs in two tiers. Stress signaling switches on first, then a controlled gene program frees dormant viral elements in the genome. Double-stranded RNA builds up and sets off antiviral and cell death pathways. Removing key genes in that chain made the cells resist the drugs. The findings name a mediator of sensitivity.
Catalog record
| CREATOR | Jianming Xu, Simon D Schwarz, Kapila Gunasekera, Roland Steinacher, Anna Kuśnierczyk, Michael O Hottiger, Primo Schär |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |