Epigenetic subtypes of high-grade T1 bladder cancer reveal intra-tumor heterogeneity and distinct interactions with tumor microenvironment
Joaquim Bellmunt, Yingtian Xie, Nuria Juanpere, Miguel Gomez Munoz, Shweta Kukreja, Sonsoles Liria Veiga, Rong Li, Xintao Qiu, Yijia Jiang, Alba Font-Tello, Marie Nunez Duarte, Ilana Epstein, Silvia Hernández-Llodrà, Marta Lorenzo, Silvia Menendez, Toni Choueiri, Myles Brown, Henry W Long, Paloma Ce · 2026
Read Epigenetic subtypes of high-grade T1 bladder cancer reveal intra-tumor heterogeneity and distinct interactions with tumor microenvironment by Joaquim Bellmunt, Yingtian Xie, Nuria Juanpere, Miguel Gomez Munoz, Shweta Kukreja, Sonsoles Liria Veiga, Rong Li, Xintao Qiu, Yijia Jiang, Alba Font-Tello, Marie Nunez Duarte, Ilana Epstein, Silvia Hernández-Llodrà, Marta Lorenzo, Silvia Menendez, Toni Choueiri, Myles Brown, Henry W Long, Paloma Ce (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13232474.txt.
Description
Joaquim Bellmunt and co-authors map hidden variety inside early bladder cancer in a 2026 paper. High-grade T1 tumors have not yet invaded muscle, but their behavior is erratic and recurrence is hard to forecast. The team layered several profiling methods, from bulk chromatin reads to single-nucleus sequencing and spatial mapping, to sort tumors by their epigenetic state rather than by looks alone.
Two shapes of the disease emerged. The common urothelial form split into an inflamed luminal-like state and a basal-like state hungry for blood vessels; about forty percent of those tumors housed both states in separate zones. The rarer micropapillary form stood apart, laced with scar-forming cells and suppressive immune cells, matching its poor outlook. The authors argue treatment should be chosen by subtype.
Catalog record
| CREATOR | Joaquim Bellmunt, Yingtian Xie, Nuria Juanpere, Miguel Gomez Munoz, Shweta Kukreja, Sonsoles Liria Veiga, Rong Li, Xintao Qiu, Yijia Jiang, Alba Font-Tello, Marie Nunez Duarte, Ilana Epstein, Silvia Hernández-Llodrà, Marta Lorenzo, Silvia Menendez, Toni Choueiri, Myles Brown, Henry W Long, Paloma Ce |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 78 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |