Base editing and nanoparticle transfection of airway cell types essential for treatment of cystic fibrosis
Erin W Kavanagh, Anya T Joynt, Audrey R Pion, Alice C Eastman, Alianna I Parr, Katherine L Starego, Manav Jain, Sydney R Shannon, Edwin J Yoo, Gregory A Newby, Stephany Y Tzeng, Neeraj Sharma, Jordan J Green, Garry R Cutting · 2026
Read Base editing and nanoparticle transfection of airway cell types essential for treatment of cystic fibrosis by Erin W Kavanagh, Anya T Joynt, Audrey R Pion, Alice C Eastman, Alianna I Parr, Katherine L Starego, Manav Jain, Sydney R Shannon, Edwin J Yoo, Gregory A Newby, Stephany Y Tzeng, Neeraj Sharma, Jordan J Green, Garry R Cutting (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13232023.txt.
Description
Erin W Kavanagh and a large team test base editing and tiny carriers as a route to treat cystic fibrosis. Their paper is from two thousand twenty-six. The disease stems from faults in one gene, which thicken mucus in the airways. Some patients gain nothing from the current gene-target drugs, so a lasting fix in airway cells is a key goal.
They fix a common splice fault in airway cells from patients, using base editor RNA. Most cell types then show far more of the gene's message. Tiny polymer carriers send the editors into lab and patient cells and bring the gene's work back to a level that matters for care. The route is non-viral and can scale.
Catalog record
| CREATOR | Erin W Kavanagh, Anya T Joynt, Audrey R Pion, Alice C Eastman, Alianna I Parr, Katherine L Starego, Manav Jain, Sydney R Shannon, Edwin J Yoo, Gregory A Newby, Stephany Y Tzeng, Neeraj Sharma, Jordan J Green, Garry R Cutting |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |