On-demand sIPN microneedles promote infected burn wound healing via microenvironment remodeling and activation of the Wnt–KLF5 regenerative axis
Xiang Fang, Boquan Qin, Aaron Qi Zhang, Zhiyuan Zhang, Tingli Wang, Shizhou Wu, Hui Zhang, Hong Duan · 2026
Read On-demand sIPN microneedles promote infected burn wound healing via microenvironment remodeling and activation of the Wnt–KLF5 regenerative axis by Xiang Fang, Boquan Qin, Aaron Qi Zhang, Zhiyuan Zhang, Tingli Wang, Shizhou Wu, Hui Zhang, Hong Duan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13231964.txt.
Description
Xiang Fang and co-authors present a microneedle patch for infected burn wounds in this 2026 paper. Severe burns heal poorly when biofilms, oxidative stress, immune upset, and low oxygen feed each other. Many microneedle designs are too weak, too slow to make, or too narrow in effect. The new patch aims to break all of those barriers at once.
The patch base mixes two polymers into a strong network. It carries three agents. One breaks up biofilms by silencing a bacterial gene. One mops up harmful oxygen species and releases oxygen. The third calms inflammation as an antioxidant. The paper also links the healing to a growth pathway in skin cells. The goal is faster, cleaner closure of hard burn wounds.
Catalog record
| CREATOR | Xiang Fang, Boquan Qin, Aaron Qi Zhang, Zhiyuan Zhang, Tingli Wang, Shizhou Wu, Hui Zhang, Hong Duan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |