A periplasmic metallochaperone (PmcY) couples Zn2+ transport to sensing in Pseudomonas aeruginosa
Paula Mihelj, Tomás Moreyra, Monserrat Olea-Flores, María Elena Carrizo, Teresita Padilla-Benavides, Daniel Raimunda · 2026
Read A periplasmic metallochaperone (PmcY) couples Zn2+ transport to sensing in Pseudomonas aeruginosa by Paula Mihelj, Tomás Moreyra, Monserrat Olea-Flores, María Elena Carrizo, Teresita Padilla-Benavides, Daniel Raimunda (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13231896.txt.
Description
Paula Mihelj and co-authors study in 2026 how a germ that causes lung and wound infections handles zinc, a metal it needs in small amounts. The germ must move zinc into the right parts of the cell while it faces harsh terms in a host. Past work by the team found two proteins that move zinc and also lower the germ's response to a key drug.
Here they study a third protein that sits in the cell's inner layers and works with one of those movers. Tests show the protein sits in the cell membrane. When the gene for it was broken, the link between zinc flow and the drug response changed. The team argues that this protein couples zinc transport to how the germ senses its state. That coupling could matter for how the germ survives drug treatment.
Catalog record
| CREATOR | Paula Mihelj, Tomás Moreyra, Monserrat Olea-Flores, María Elena Carrizo, Teresita Padilla-Benavides, Daniel Raimunda |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |