Gambogic acid induces cell death via covalent binding with PRDX1 to regulate ER stress and autophagy
Jinyan Wang, Wei Zhang, Li Yang, Xiaoru Zhong, Jinhuan Ou, Ashok Iyaswamy, Xin Gu, Chuanbin Yang, Bing Guo, Mingjun Shi, Jigang Wang · 2026
Read Gambogic acid induces cell death via covalent binding with PRDX1 to regulate ER stress and autophagy by Jinyan Wang, Wei Zhang, Li Yang, Xiaoru Zhong, Jinhuan Ou, Ashok Iyaswamy, Xin Gu, Chuanbin Yang, Bing Guo, Mingjun Shi, Jigang Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13231703.txt.
Description
Jinyan Wang and colleagues pin down in 2026 how a tree resin compound kills kidney cancer cells by latching onto one protein. Gambogic acid, drawn from a Southeast Asian tree, is already in mid-stage cancer trials. A battery of cell tests measured survival, death signals, recycling activity, and stress inside treated kidney cancer cells.
The compound locked directly onto PRDX1, an enzyme that normally mops up harmful oxygen byproducts. With that guard disabled, reactive oxygen piled up and stressed the cell folding compartment, which then pushed the cell toward death. Adding extra PRDX1 shielded cells from much of the damage, confirming the target role. Kidney cancer drug design may exploit that single weak point.
Catalog record
| CREATOR | Jinyan Wang, Wei Zhang, Li Yang, Xiaoru Zhong, Jinhuan Ou, Ashok Iyaswamy, Xin Gu, Chuanbin Yang, Bing Guo, Mingjun Shi, Jigang Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |