Dynamic cellular heterogeneity revealed through a time-resolved single-cell atlas: assessment of porcine intestinal organoids as an in vitro model for deoxynivalenol and zearalenone
Tae Hong Kang, Jung Woong Yoon, Seung Joon Lim, Chae Hyun Lee, Yo Han Lee, Suhyeon Yun, Heejun Jung, Hyun Jun Jang, Tae Hyun Kim, Sang In Lee · 2026
Read Dynamic cellular heterogeneity revealed through a time-resolved single-cell atlas: assessment of porcine intestinal organoids as an in vitro model for deoxynivalenol and zearalenone by Tae Hong Kang, Jung Woong Yoon, Seung Joon Lim, Chae Hyun Lee, Yo Han Lee, Suhyeon Yun, Heejun Jung, Hyun Jun Jang, Tae Hyun Kim, Sang In Lee (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13231639.txt.
Description
Tae Hong Kang and colleagues build in 2026 a single-cell atlas of pig gut organoids grown over time in the lab. Mini guts grown from intestinal tissue can mirror the mix of cell types in the real small intestine. Samples from three gut regions were grown for many passages while gene activity was tracked cell by cell.
The organoids kept a close genetic match to native tissue and held stem, absorptive, and several secretory cell types. Their mix shifted in an orderly way as cultures aged, showing lively internal diversity. Two mold toxins common in animal feed then cut cell survival, weakened the gut barrier, and skewed cell production. A model that reacts this realistically could screen feed and food toxins with fewer live animal tests.
Catalog record
| CREATOR | Tae Hong Kang, Jung Woong Yoon, Seung Joon Lim, Chae Hyun Lee, Yo Han Lee, Suhyeon Yun, Heejun Jung, Hyun Jun Jang, Tae Hyun Kim, Sang In Lee |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |