Understanding trial designs and acceptability of participation in an HIV vaccine trial with concurrent randomisation to oral pre-exposure prophylaxis in East and Southern Africa: a longitudinal qualitative study
Rachel Kawuma, Sarah Nakamanya, Edith Tarimo, Rujeko Samanthia Chimukuche, Jane Ambindwile, Doreen Pamba, Sylvia Kusemererwa, Patricia Munseri, Nishanta Singh, Karine Dubé, Sheena McCormack, Eugene Ruzagira, Janet Seeley, Rachel Kawuma, Rachel Kawuma, Sarah Nakamanya, Edith Tarimo, Doreen Pamba, Syl · 2026
Read Understanding trial designs and acceptability of participation in an HIV vaccine trial with concurrent randomisation to oral pre-exposure prophylaxis in East and Southern Africa: a longitudinal qualitative study by Rachel Kawuma, Sarah Nakamanya, Edith Tarimo, Rujeko Samanthia Chimukuche, Jane Ambindwile, Doreen Pamba, Sylvia Kusemererwa, Patricia Munseri, Nishanta Singh, Karine Dubé, Sheena McCormack, Eugene Ruzagira, Janet Seeley, Rachel Kawuma, Rachel Kawuma, Sarah Nakamanya, Edith Tarimo, Doreen Pamba, Syl (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13231623.txt.
Description
Rachel Kawuma and the PrEPVacc trial team published a longitudinal qualitative study in twenty twenty-six on whether trial participants actually understood the unusual HIV prevention trial they had joined. The East and Southern African trial tested vaccines and, in a second randomization, preventive pills at once. One hundred five participants were interviewed three times across a year, and over a hundred more joined focus groups.
Repeated information sessions led by health workers gradually built real understanding of the design. Participants widely recognized the pills as proven protection alongside the experimental vaccines. The study traces what helped comprehension and what influenced joining. For trial designers, it is evidence that complex designs can be made legible to the people inside them.
Catalog record
| CREATOR | Rachel Kawuma, Sarah Nakamanya, Edith Tarimo, Rujeko Samanthia Chimukuche, Jane Ambindwile, Doreen Pamba, Sylvia Kusemererwa, Patricia Munseri, Nishanta Singh, Karine Dubé, Sheena McCormack, Eugene Ruzagira, Janet Seeley, Rachel Kawuma, Rachel Kawuma, Sarah Nakamanya, Edith Tarimo, Doreen Pamba, Syl |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |