Interplay of the ribosome A and CAR sites
Mitsu Raval, Yancheng Zhou, Miki Lynch, Daniel Krizanc, Kelly M Thayer, Michael P Weir · 2026
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Description
Mitsu Raval and colleagues explore in 2026 how two nearby sites on the ribosome influence each other during protein building. The ribosome reads messenger RNA codons at its A site, where the next building block arrives. Right beside it sits the CAR surface, a small motif that touches the codon waiting to enter.
Computer simulations of molecular motion showed the two sites shape each other bonding and stacking patterns. Effects depended on which letters the nearby codon carried, so sequence context matters beyond the codon being read. The link hints that the ribosome tunes its reading speed to local message content. Finer control of elongation could matter for cells that must balance speed against accuracy.
Catalog record
| CREATOR | Mitsu Raval, Yancheng Zhou, Miki Lynch, Daniel Krizanc, Kelly M Thayer, Michael P Weir |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |