Tirzepatide for weight and behavior management in a patient with Smith-Magenis syndrome
X Charlene Liao, Tao Huang, David S Hong, Liqun Luo · 2026
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Description
X Charlene Liao and colleagues describe in 2026 a woman with a rare developmental syndrome whose weight and behavior improved on tirzepatide. Smith-Magenis syndrome brings learning disability, strong food seeking, obesity, and hard-to-manage aggression. The thirty-one-year-old had carried obesity since childhood and had not responded well to standard behavior care.
Weekly tirzepatide, raised to a modest dose, led to a loss of close to a tenth of her body weight over ten months. Fasting glucose improved as well, and caregivers saw less food seeking and impulsivity at home. Measured aggression scores fell in a clear way during treatment. One well tolerated case cannot prove benefit for the syndrome, yet it invites careful study in similar patients.
Catalog record
| CREATOR | X Charlene Liao, Tao Huang, David S Hong, Liqun Luo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 18 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |