Clinico-genomic nomograms for estimation of survival risk in metastatic castrate-resistant prostate cancer
Manish Kohli, Anushka Shankar, Jennifer Lloyd, Liang Wang, Xingyue Huo, Muhammad Zaki Fadlullah, Aik Choon Tan, Joseph Finkelstein · 2026
Read Clinico-genomic nomograms for estimation of survival risk in metastatic castrate-resistant prostate cancer by Manish Kohli, Anushka Shankar, Jennifer Lloyd, Liang Wang, Xingyue Huo, Muhammad Zaki Fadlullah, Aik Choon Tan, Joseph Finkelstein (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13231001.txt.
Description
Men with advanced prostate cancer that no longer answers hormone care face hard choices about risk. Manish Kohli and co-authors built scoring charts to estimate survival in that setting in 2026. One chart uses clinical factors alone, drawn from a public data set of over one thousand patients. A second chart adds gene change scores from blood and tumor samples in a smaller set.
The gene scores rest on gains and losses in eleven genes tied to outcome. Charts give survival odds at one, two, and three years for a single patient. Time-based accuracy checks judged how well each chart sorted patients. Public data access made the larger chart possible without new trials. The authors aim to sharpen risk talks between doctors and patients.
Catalog record
| CREATOR | Manish Kohli, Anushka Shankar, Jennifer Lloyd, Liang Wang, Xingyue Huo, Muhammad Zaki Fadlullah, Aik Choon Tan, Joseph Finkelstein |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |