Intracellular logic computing with DNA tetrahedron processors enables precision cancer theranostics
Yang Gao, Yun Wang, Yunlong Qin, Geru Zhang, Shaojingya Gao, Wen Chen, Siyi Yang, Xiao Yang, Yuanlin Tang, Yao He, Yunfeng Lin, Itamar Willner, Taoran Tian, Xiaoxiao Cai · 2026
Read Intracellular logic computing with DNA tetrahedron processors enables precision cancer theranostics by Yang Gao, Yun Wang, Yunlong Qin, Geru Zhang, Shaojingya Gao, Wen Chen, Siyi Yang, Xiao Yang, Yuanlin Tang, Yao He, Yunfeng Lin, Itamar Willner, Taoran Tian, Xiaoxiao Cai (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13230932.txt.
Description
Yang Gao and colleagues build in 2026 tiny DNA frames that compute inside living cells and release treatment only on the right signal. Each tetrahedron reads three small RNA markers at once and can carry out seven kinds of logic rules. A drug-carrying RNA stays locked until the chosen rule is satisfied.
One version used a majority rule across three markers linked to breast cancer cells. It silenced a survival gene called survivin only in cells showing the target pattern, sparing other cell types. Tumors shrank strongly in dish and animal tests, with little off-target harm reported. Reading several markers at once sharpens the line between cancer and healthy tissue for future smart medicines.
Catalog record
| CREATOR | Yang Gao, Yun Wang, Yunlong Qin, Geru Zhang, Shaojingya Gao, Wen Chen, Siyi Yang, Xiao Yang, Yuanlin Tang, Yao He, Yunfeng Lin, Itamar Willner, Taoran Tian, Xiaoxiao Cai |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |