Lysophosphatidic Acid Reduces Ischemic Brain Injury by Attenuating Vascular Permeability Through LPA4 Receptor Signaling
Shintaro Yamada, Kazuhiro Takara, Naoi Hosoe, Anna Shimizu, Yumiko Hayashi, Lamri Lynda, Takayuki Sonoda, Kenichiro Kikuta, Hiroyasu Kidoya · 2026
Read Lysophosphatidic Acid Reduces Ischemic Brain Injury by Attenuating Vascular Permeability Through LPA4 Receptor Signaling by Shintaro Yamada, Kazuhiro Takara, Naoi Hosoe, Anna Shimizu, Yumiko Hayashi, Lamri Lynda, Takayuki Sonoda, Kenichiro Kikuta, Hiroyasu Kidoya (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13230236.txt.
Description
Shintaro Yamada and colleagues report in 2026 that a fat-like signaling molecule reduced stroke damage in mice by protecting blood vessels. After a blocked brain artery, the blood-brain barrier often leaks and worsens swelling and injury. The team gave lysophosphatidic acid right after the blockage and checked the brain two days later.
Treated mice had much smaller damaged areas and less swelling than untreated animals. Barrier leak tests showed tighter vessels, and a key sealing protein stayed in place in vessel walls. Cell data pointed to one receptor, LPA4, sitting on vessel cells in the injured zone. Mice lacking that receptor gained no benefit, which ties the protection to that pathway.
Catalog record
| CREATOR | Shintaro Yamada, Kazuhiro Takara, Naoi Hosoe, Anna Shimizu, Yumiko Hayashi, Lamri Lynda, Takayuki Sonoda, Kenichiro Kikuta, Hiroyasu Kidoya |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |