Polydatin alleviates adenine-induced nephropathy in mice
Tao Sheng, Tianhong Ma, Xin Jin, Debin Chen, Shipeng Che, Jie Wang, Jiadu Shen, Chaoqun Shi, Qiang Li, Yixin Sun, Deqing Chen, Guangtao Xu · 2026
Read Polydatin alleviates adenine-induced nephropathy in mice by Tao Sheng, Tianhong Ma, Xin Jin, Debin Chen, Shipeng Che, Jie Wang, Jiadu Shen, Chaoqun Shi, Qiang Li, Yixin Sun, Deqing Chen, Guangtao Xu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13228186.txt.
Description
Tao Sheng and colleagues test a 2026 plant compound, polydatin, in mice with kidney damage induced by adenine, a standard model of uric-acid-related kidney injury. The model produces blocked tubules, inflammation, cell death, and progressive scarring. Fifty male mice were divided among a healthy group, an untreated injury group, and three treatment groups receiving polydatin or one of two standard uric-acid drugs.
Injured kidneys showed clearly abnormal function and tissue structure under the microscope. Polydatin treatment significantly improved those measures, protecting both the tissue architecture and kidney performance. The authors link the benefit to calming immune inflammation, cell death, and scarring processes, and they present the work as groundwork for possible clinical use.
Catalog record
| CREATOR | Tao Sheng, Tianhong Ma, Xin Jin, Debin Chen, Shipeng Che, Jie Wang, Jiadu Shen, Chaoqun Shi, Qiang Li, Yixin Sun, Deqing Chen, Guangtao Xu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |