Indirect Treatment Comparison of Riociguat Replacement Therapy and Selexipag Add-on Therapy in Patients With Pulmonary Arterial Hypertension: Results From a Systematic Review
Ji-Eun An, Jahyun Cho, Min Ju Kim, Ah-Yeon Lee, Woo-Jeong Sim, Gyeong-U Hong, Soo Hyun Lee, Dong-Sook Kim, Sun-Young Yi, Kyung-Min Lee, Su-Yeon Yu · 2026
Read Indirect Treatment Comparison of Riociguat Replacement Therapy and Selexipag Add-on Therapy in Patients With Pulmonary Arterial Hypertension: Results From a Systematic Review by Ji-Eun An, Jahyun Cho, Min Ju Kim, Ah-Yeon Lee, Woo-Jeong Sim, Gyeong-U Hong, Soo Hyun Lee, Dong-Sook Kim, Sun-Young Yi, Kyung-Min Lee, Su-Yeon Yu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13227382.txt.
Description
Ji-Eun An and colleagues indirectly compare a 2026 pair of escalation drugs for pulmonary arterial hypertension, a disease of stiffening lung arteries. Patients already on two standard drug classes often respond inadequately, and two next-step options exist: switching to riociguat, or adding selexipag. No trial has tested them head to head, so the team compared them through their separate trials against the shared background therapy.
Three randomised trials fed the analysis. On clinical worsening, walking distance, and a heart-strain blood marker, the two strategies showed no significant differences. Overall side-effect risk also looked similar. Wide confidence intervals reflect the indirect method's limits, but the results give clinicians a first comparative foothold where direct evidence is absent.
Catalog record
| CREATOR | Ji-Eun An, Jahyun Cho, Min Ju Kim, Ah-Yeon Lee, Woo-Jeong Sim, Gyeong-U Hong, Soo Hyun Lee, Dong-Sook Kim, Sun-Young Yi, Kyung-Min Lee, Su-Yeon Yu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |