Central nervous system resilience to cyclophosphamide: preserved behavior, astrocytes and LGALS3 expression in immunosuppressed mice
Rogério Aires, Alex de Camargo Coque, Lucas Maruchi Delapena Silva, Arila Adorno Scorzafava Gonçalves, Liebert Bernardes Carvalho, Rafael Lopes Correia Tagliaferri, Elizabeth Cristina Perez Hurtado, Eduardo Bondan, José Guilherme Xavier, Maria Martha Bernardi, Rodrigo Augusto Foganholi da Silva · 2026
Read Central nervous system resilience to cyclophosphamide: preserved behavior, astrocytes and LGALS3 expression in immunosuppressed mice by Rogério Aires, Alex de Camargo Coque, Lucas Maruchi Delapena Silva, Arila Adorno Scorzafava Gonçalves, Liebert Bernardes Carvalho, Rafael Lopes Correia Tagliaferri, Elizabeth Cristina Perez Hurtado, Eduardo Bondan, José Guilherme Xavier, Maria Martha Bernardi, Rodrigo Augusto Foganholi da Silva (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13227206.txt.
Description
Rogério Aires and colleagues check a 2026 mouse study of whether cyclophosphamide, a drug widely used to suppress the immune system in experiments, quietly disturbs the brain. If it did, countless neuroimmune studies could be confounded. Male mice received weekly injections for three or four weeks, then underwent behaviour batteries, brain tissue checks, and gene-expression measurement.
Immune suppression clearly took hold in the body, with slower weight gain and altered white-cell counts. Behaviour, though, barely moved, showing only mild, passing changes in strength and sickness-like signs. Brain tissue showed no structural damage and no activation of star-shaped support cells. One gene, Lgals3, rose significantly in the brain, a molecular footnote in an otherwise reassuring picture of central resilience.
Catalog record
| CREATOR | Rogério Aires, Alex de Camargo Coque, Lucas Maruchi Delapena Silva, Arila Adorno Scorzafava Gonçalves, Liebert Bernardes Carvalho, Rafael Lopes Correia Tagliaferri, Elizabeth Cristina Perez Hurtado, Eduardo Bondan, José Guilherme Xavier, Maria Martha Bernardi, Rodrigo Augusto Foganholi da Silva |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |