MDNA : a software module for DNA structure generation and analysis
Thor van Heesch, Enrico Skoruppa, Peter G Bolhuis, Helmut Schiessel, Jocelyne Vreede · 2026
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Description
Thor van Heesch and co-authors introduced a software toolkit called MDNA in two thousand twenty-six. The toolkit helps scientists build and study complex shapes made of DNA. Models like these are starting points for computer tests of how molecules move and act. Older tools handled straight DNA well but struggled with bent or joined structures.
MDNA builds DNA shapes by mapping them onto smooth curves. It can add common chemical changes found in living cells. It can also add shifts in how the base pairs link up. A search method then refines each shape to use less energy. Built-in tools measure the shape and track how it changes over time.
Catalog record
| CREATOR | Thor van Heesch, Enrico Skoruppa, Peter G Bolhuis, Helmut Schiessel, Jocelyne Vreede |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |