Non-decameric NLRP3 reveals a TGN/MTOC-distal pathway of inflammasome activation
María Mateo-Tórtola, Inga V. Hochheiser, Gaopeng Li, Lukas Funk, Atousa Hashemi, Xiao Liu, Jane Torp, Lena Erlebach, András Szolek, Jelena Grga, Francesca Bork, Jana S. Müller, Deborah Kronenberg-Versteeg, Matthias Geyer, Alexander N. R. Weber, Ana Tapia-Abellán · 2026
Read Non-decameric NLRP3 reveals a TGN/MTOC-distal pathway of inflammasome activation by María Mateo-Tórtola, Inga V. Hochheiser, Gaopeng Li, Lukas Funk, Atousa Hashemi, Xiao Liu, Jane Torp, Lena Erlebach, András Szolek, Jelena Grga, Francesca Bork, Jana S. Müller, Deborah Kronenberg-Versteeg, Matthias Geyer, Alexander N. R. Weber, Ana Tapia-Abellán (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13226650.txt.
Description
María Mateo-Tórtola and co-authors uncover a 2026 second route by which the NLRP3 inflammasome, an inflammation trigger implicated from infection to Alzheimer's disease, can switch on. The protein normally sits in an inactive ten-part cage and activates near two cellular landmarks. The team built a shortened variant that cannot form the cage, then watched activation with high-resolution microscopy in human immune cells.
A standard stimulus triggered the fast cage-dependent route as expected. It also engaged a slower route used by the small assemblies, operating away from both landmarks. That second pathway dominated in neutrophils, the most abundant white blood cells. Two parallel activation modes help explain why NLRP3-driven inflammation varies so much between cell types and diseases.
Catalog record
| CREATOR | María Mateo-Tórtola, Inga V. Hochheiser, Gaopeng Li, Lukas Funk, Atousa Hashemi, Xiao Liu, Jane Torp, Lena Erlebach, András Szolek, Jelena Grga, Francesca Bork, Jana S. Müller, Deborah Kronenberg-Versteeg, Matthias Geyer, Alexander N. R. Weber, Ana Tapia-Abellán |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 97 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |