Distinct cellular effects of myotonic dystrophy type 2 repeat-associated non-AUG tetrapeptides
Marta Marzullo, Assia De Simone, Marta Terribili, Michela Di Salvio, Degisew Yinur Mengistu, Maria Patrizia Somma, Rodrigo D'Amico, Gianluca Canettieri, Gianluca Cestra, Laura Ciapponi · 2026
Read Distinct cellular effects of myotonic dystrophy type 2 repeat-associated non-AUG tetrapeptides by Marta Marzullo, Assia De Simone, Marta Terribili, Michela Di Salvio, Degisew Yinur Mengistu, Maria Patrizia Somma, Rodrigo D'Amico, Gianluca Canettieri, Gianluca Cestra, Laura Ciapponi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13225714.txt.
Description
Ten researchers led by Marta Marzullo studied two odd proteins made in myotonic dystrophy type two, a gene disorder that weakens muscles and harms many organs. The disease stems from a repeated gene stretch, which cells can read from a wrong start point, yielding two short repeat proteins. The team grew each in fruit flies to split their effects.
Both proteins cut survival, damaged eyes, and slowed movement. The first piled up in the cell's protein factory core and jammed its cleanup system. The second shifted a stress-related protein in human cells and in patient muscle cells. The authors say the pair harm cells in distinct ways that likely add up.
Catalog record
| CREATOR | Marta Marzullo, Assia De Simone, Marta Terribili, Michela Di Salvio, Degisew Yinur Mengistu, Maria Patrizia Somma, Rodrigo D'Amico, Gianluca Canettieri, Gianluca Cestra, Laura Ciapponi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |