Transgenic mouse models for investigating human DUX4 expression during development and its roles in FSHD pathophysiology
Yosuke Hiramuki, Charis L. Himeda, Peter L. Jones, Takako I. Jones · 2026
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Description
Yosuke Hiramuki and co-authors build mouse models for a muscle disease gene in a 2026 paper. The gene DUX4 should switch off after early development. In FSHD muscular dystrophy, it wrongly switches back on in muscle.
The gene is poorly conserved outside primates, blocking study. Reporter mice carry human DUX4 control elements instead. Cells that ever turned the gene on stay marked for life. Marked lineages appeared in embryos and in adult tissues. That map shows where misexpression could do its damage. Readers get a new tool for tracing a disease gene's footprints.
Catalog record
| CREATOR | Yosuke Hiramuki, Charis L. Himeda, Peter L. Jones, Takako I. Jones |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |