A zebrafish luminescent biosensor for kidney tubulopathy, metal toxicity and drug screening
Han Lai, Monica Goldade, Svenja Aline Keller, Isabelle Worms, Alessandro Luciani, Stephan C. F. Neuhauss, Vera I. Slaveykova, Olivier Devuyst, Zhiyong Chen · 2026
Read A zebrafish luminescent biosensor for kidney tubulopathy, metal toxicity and drug screening by Han Lai, Monica Goldade, Svenja Aline Keller, Isabelle Worms, Alessandro Luciani, Stephan C. F. Neuhauss, Vera I. Slaveykova, Olivier Devuyst, Zhiyong Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13225708.txt.
Description
Lai and eight co-authors built a glowing fish test for kidney trouble in this study from twenty twenty-six. Zebrafish kidneys filter blood much like the human kidney's first segment. When that segment fails, small proteins leak into urine. The team fused a vitamin D carrier protein to a light-making enzyme in a new fish line.
Leaked protein in the water then glows, giving a simple readout of tubule health. The sensor proved reliable in fish models of inherited tubule diseases. It also flagged damage from two harsh drugs and from cadmium and copper pollution. New detail emerged on how those metals hurt the tubule. The authors offer the line as a drug screening platform.
Catalog record
| CREATOR | Han Lai, Monica Goldade, Svenja Aline Keller, Isabelle Worms, Alessandro Luciani, Stephan C. F. Neuhauss, Vera I. Slaveykova, Olivier Devuyst, Zhiyong Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |