Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework
Zhuoqi Zheng, Bo Zhang, Bozitao Zhong, Jinyu Yu, Kexin Liu, Zhengxin Li, Junjie Zhu, Ting Wei, Hai-Feng Chen, Gaetano Montelione, Gaetano Montelione, Gaetano Montelione · 2026
Read Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework by Zhuoqi Zheng, Bo Zhang, Bozitao Zhong, Jinyu Yu, Kexin Liu, Zhengxin Li, Junjie Zhu, Ting Wei, Hai-Feng Chen, Gaetano Montelione, Gaetano Montelione, Gaetano Montelione (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13225634.txt.
Description
Zhuoqi Zheng and co-authors rank in this 2026 study the machines that dream up protein backbones. De novo design has surged, but each generator was graded on its own turf. Their framework, Scaffold-Lab, scores seven leading methods on one field across designability, novelty, variety, speed, and structural soundness.
Two bottlenecks stand out: spinning long proteins from scratch, and rebuilding a given functional motif faithfully. Most methods stumble at one or both. The authors present the ranking as a map of where the field stands and where the next effort should dig, for designers choosing tools today. New entrants now know the bar they face. Labs can rerun the same bench each year.
Catalog record
| CREATOR | Zhuoqi Zheng, Bo Zhang, Bozitao Zhong, Jinyu Yu, Kexin Liu, Zhengxin Li, Junjie Zhu, Ting Wei, Hai-Feng Chen, Gaetano Montelione, Gaetano Montelione, Gaetano Montelione |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |