Prevalence of GJB2 gene mutations in nonsyndromic hearing impairments: A systematic review and meta-analysis
Ruijie Feng, Ernest Mangantig, Wan Shahriman Yushdie Wan Yusoff, Hui Li, Xiaoze Li, Mohd Nazri Abu · 2026
Read Prevalence of GJB2 gene mutations in nonsyndromic hearing impairments: A systematic review and meta-analysis by Ruijie Feng, Ernest Mangantig, Wan Shahriman Yushdie Wan Yusoff, Hui Li, Xiaoze Li, Mohd Nazri Abu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13225560.txt.
Description
Ruijie Feng and co-authors pool global data on GJB2 gene mutations in inherited hearing loss without other syndromes in a 2026 review. This gene, which builds a gap-junction protein, is a top cause of such deafness, yet rates vary by population.
The meta-analysis covered fifty-one studies from twenty-four countries and near nineteen thousand patients. About a quarter carried a GJB2 mutation overall. Five hotspot variants were tracked, led by two deletion types common in Asia and Europe. Rates peaked in the Middle East at well over a third and ran lowest in Africa. The authors back region-tailored gene screening so diagnosis, counseling, and early help reach families faster.
Catalog record
| CREATOR | Ruijie Feng, Ernest Mangantig, Wan Shahriman Yushdie Wan Yusoff, Hui Li, Xiaoze Li, Mohd Nazri Abu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |