Association of depression with keratitis: A bidirectional 2-sample Mendelian randomization study
Yujian Zhang, Donghua Niu, Mengjie Chen, Min Ji, Junfang Zhang, Rongwei Zhou · 2026
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Description
Yujian Zhang and co-authors test whether depression helps cause eye surface harm in a 2026 study. The harm, keratitis, is swelling of the clear front of the eye. Past reports linked the two, but plain links can mislead. The team used a gene-based method in both ways. Gene marks for depression served as stand-ins to test its effect on keratitis, and marks for keratitis did the same in reverse.
Depression raised keratitis risk by about 17 percent in the main test. Three back-up methods pointed the same way. Stress checks found no strong bias and no single gene mark drove the result. The reverse test found no effect of keratitis on depression. The authors urge eye teams to weigh mood care in keratitis work. They also call for work on the shared roots of the two ills.
Catalog record
| CREATOR | Yujian Zhang, Donghua Niu, Mengjie Chen, Min Ji, Junfang Zhang, Rongwei Zhou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |