Mesial temporal shape asymmetry as a neuro-imaging correlate of epilepsy in mild cognitive impairment and dementia
Ifrah Zawar, Shen Zhu, Mark Quigg, Jaideep Kapur, Alice D Lam, Rani A Sarkis, Anelyssa D’Abreu, Carol Manning, P Thomas Fletcher · 2026
Read Mesial temporal shape asymmetry as a neuro-imaging correlate of epilepsy in mild cognitive impairment and dementia by Ifrah Zawar, Shen Zhu, Mark Quigg, Jaideep Kapur, Alice D Lam, Rani A Sarkis, Anelyssa D’Abreu, Carol Manning, P Thomas Fletcher (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13225267.txt.
Description
Ifrah Zawar and co-authors ask whether the two sides of the brain's memory structures differ in shape when epilepsy comes with cognitive impairment, in a 2026 multicentre study. Epilepsy is common in Alzheimer's disease and related dementias, and both conditions reshape the hippocampus and amygdala deep in the temporal lobe. The team drew people from thirty-nine American Alzheimer's centers, spanning records from 2005 to 2021.
Patients with cognitive impairment and epilepsy were matched to patients without epilepsy and to healthy controls. Software split the brain scans, and the team worked out left-minus-right asymmetry for volume and surface shape of each structure, using hundreds of surface points. Comparisons split Alzheimer's cases from other dementia cases in each group. The study tests whether mesial temporal asymmetry is a clear imaging sign of epilepsy here. The sign is little studied and could help flag which dementia patients live with seizures.
Catalog record
| CREATOR | Ifrah Zawar, Shen Zhu, Mark Quigg, Jaideep Kapur, Alice D Lam, Rani A Sarkis, Anelyssa D’Abreu, Carol Manning, P Thomas Fletcher |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |