MicroRNAs in Asthma: A Replication-Based Review of Human Evidence
Parham Hadikhani, Shraddha Piparia, Rinku Sharma, Michael McGeachie, Kelan G Tantisira · 2026
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Description
Parham Hadikhani and co-authors filter a 2026 asthma literature on microRNAs, tiny bits of RNA that fine-tune gene activity and shape airway inflammation. Many candidate microRNAs have been named, but findings often conflict or lack checks by other teams. Searching studies from 2009 to 2025, the team applied strict replication rules to keep only links seen again in other cohorts.
That filter shrank 299 records to a small set of strong candidates. Two molecules, miR-146a and miR-1246, recurred most often and connect to inflammation signals, airway lining failure, and steroid response. Replicated microRNAs also tracked severity, flare frequency, and lung function, strengthening their case as biomarkers or treatment targets.
Catalog record
| CREATOR | Parham Hadikhani, Shraddha Piparia, Rinku Sharma, Michael McGeachie, Kelan G Tantisira |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 100 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |