Human Epidermal Growth Factor Receptor 2 Quantification Using Computational Pathology to Identify Novel Biomarkers for Trastuzumab Deruxtecan–Treated Human Epidermal Growth Factor Receptor 2–Positive Gastric Cancer
Ansh Kapil, Henrik Failmezger, Yu Fu, Andreas Spitzmüller, Jessica Chan, Susanne Haneder, Anatoliy Shumilov, Alice Barkell, Toshihiro Oguma, Koichiro Inaki, Fumitaka Suto, John Allard, Jeeyun Lee, Arthur W Lambert, Markus Schick, J Carl Barrett, Günter Schmidt, Hadassah Sade, Mark Gustavson, Daniell · 2026
Read Human Epidermal Growth Factor Receptor 2 Quantification Using Computational Pathology to Identify Novel Biomarkers for Trastuzumab Deruxtecan–Treated Human Epidermal Growth Factor Receptor 2–Positive Gastric Cancer by Ansh Kapil, Henrik Failmezger, Yu Fu, Andreas Spitzmüller, Jessica Chan, Susanne Haneder, Anatoliy Shumilov, Alice Barkell, Toshihiro Oguma, Koichiro Inaki, Fumitaka Suto, John Allard, Jeeyun Lee, Arthur W Lambert, Markus Schick, J Carl Barrett, Günter Schmidt, Hadassah Sade, Mark Gustavson, Daniell (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13225111.txt.
Description
Ansh Kapil and a large collaboration test a 2026 software method that predicts who gains from a targeted stomach cancer drug. The drug, trastuzumab deruxtecan, attacks cells carrying the HER2 protein, and entry normally rests on a rough staining score. Software instead measures HER2 levels across tumour slides from two trials.
Two software-derived signatures stood out: a spatial proximity score and the density of HER2-positive cells within the tumour tissue. Patients flagged positive by these measures lived significantly longer on the drug in the first trial. The same signatures then validated in the second trial, suggesting finer measurement could sharpen patient selection.
Catalog record
| CREATOR | Ansh Kapil, Henrik Failmezger, Yu Fu, Andreas Spitzmüller, Jessica Chan, Susanne Haneder, Anatoliy Shumilov, Alice Barkell, Toshihiro Oguma, Koichiro Inaki, Fumitaka Suto, John Allard, Jeeyun Lee, Arthur W Lambert, Markus Schick, J Carl Barrett, Günter Schmidt, Hadassah Sade, Mark Gustavson, Daniell |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |