Multicellular senescence programs in the aged heart
Laurent Bultot, Natsuko Tsurudome, Emi Kumazaki, Ippei Shimizu · 2026
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Description
Laurent Bultot, Natsuko Tsurudome, Emi Kumazaki, and Ippei Shimizu review how cellular senescence, spread across many cell types, ages the heart, in this 2026 paper. Aging heart cells accumulate damage, from frayed chromosome ends to scrambled gene control, and many slip into senescence, a stalled state that broadcasts inflammatory signals. Muscle, vessel, scar, and immune cells all take part.
The tissue results are familiar: thinning micro vessels, fibrosis, thickened walls, and faltering adaptation, a soil for heart failure and rhythm disorders. Yet senescence is not one thing. Brief, injury triggered states help repair, while chronic ones spread harm. New measurements can now estimate the heart's biological age from blood and images. Early animal work shows drugs that clear or calm senescent cells can partly restore the heart.
Catalog record
| CREATOR | Laurent Bultot, Natsuko Tsurudome, Emi Kumazaki, Ippei Shimizu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 92 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |