Paediatric DNA methylation profile scores: a systematic review and open-source atlas
Isabel K Schuurmans, Serena Defina, APC Hermans, Alexander Neumann, Matthew Suderman, Paul Yousefi, Janine F Felix, Charlotte AM Cecil · 2026
Read Paediatric DNA methylation profile scores: a systematic review and open-source atlas by Isabel K Schuurmans, Serena Defina, APC Hermans, Alexander Neumann, Matthew Suderman, Paul Yousefi, Janine F Felix, Charlotte AM Cecil (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13224112.txt.
Description
Isabel K Schuurmans and colleagues review a 2026 body of work on DNA methylation scores in children and teenagers. Such scores compress chemical marks at many DNA sites into one number that can signal exposures, biological states, or disease risk. Most scores were built in adults, yet use in early life is growing quickly.
Surveying 119 studies covering 828 scores, the reviewers found wide variation in design and reporting. Many studies applied scores trained in mismatched age groups, tissues, platforms, or ancestries, which can distort performance. To help researchers choose wisely, the team built DEMETRA, a searchable online atlas cataloguing early-life scores and their origins.
Catalog record
| CREATOR | Isabel K Schuurmans, Serena Defina, APC Hermans, Alexander Neumann, Matthew Suderman, Paul Yousefi, Janine F Felix, Charlotte AM Cecil |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |