Curcuma-derived nanovesicle-loaded ROS-responsive hydrogels reprogram iron metabolism to enhance cartilage regeneration after microfracture
Yuhao Mu, Hao Li, Ruiyang Zhang, Runmeng Li, Ke Ma, Fakai Li, Yongkang Yang, Yiming Ren, Zheng Guo, Tianze Gao, Chao Wang, Jiafeng Miao, Qinlin Yan, Juan Guan, Shuyun Liu, Quanyi Guo · 2026
Read Curcuma-derived nanovesicle-loaded ROS-responsive hydrogels reprogram iron metabolism to enhance cartilage regeneration after microfracture by Yuhao Mu, Hao Li, Ruiyang Zhang, Runmeng Li, Ke Ma, Fakai Li, Yongkang Yang, Yiming Ren, Zheng Guo, Tianze Gao, Chao Wang, Jiafeng Miao, Qinlin Yan, Juan Guan, Shuyun Liu, Quanyi Guo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13224031.txt.
Description
Yuhao Mu and co-authors present a study dated 2026 on healing cartilage after a common knee procedure. Microfracture surgery pokes small holes in bone to spark cartilage repair, but the new tissue is usually the weaker fibrous kind. The team traced why that happens and tested a gel designed to steer repair toward the glassy, durable kind.
Early iron buildup at the repair site tracked with a form of cell death called ferroptosis. Stem cells at a branching point could become either cartilage type, and that cell death tipped the choice. Tiny vesicles from turmeric plants carried a molecule that damped the death pathway. The team loaded them into an injectable gel that releases its cargo when it senses reactive oxygen.
Catalog record
| CREATOR | Yuhao Mu, Hao Li, Ruiyang Zhang, Runmeng Li, Ke Ma, Fakai Li, Yongkang Yang, Yiming Ren, Zheng Guo, Tianze Gao, Chao Wang, Jiafeng Miao, Qinlin Yan, Juan Guan, Shuyun Liu, Quanyi Guo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 85 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |