CTSZ-dependent anoikis resistance enhances malignant characters of glioblastoma via NF-κB signaling
Yiyang Cao, Wei Wu, Yichang Wang, Beichen Zhang, Haoyu Zhou, Mingjing Zhou, Wei Chen, Maode Wang, Jia Wang · 2026
Read CTSZ-dependent anoikis resistance enhances malignant characters of glioblastoma via NF-κB signaling by Yiyang Cao, Wei Wu, Yichang Wang, Beichen Zhang, Haoyu Zhou, Mingjing Zhou, Wei Chen, Maode Wang, Jia Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13224022.txt.
Description
Yiyang Cao and co-authors report a 2026 glioblastoma study focused on anoikis, the self-destruct process that normally kills cells torn away from their surroundings. Brain tumours that resist this process can invade more easily and withstand treatment. The team identified an enzyme called cathepsin Z, or CTSZ, as a driver of that resistance.
Tumour tissue carried higher CTSZ levels than expected, and higher levels tracked with worse patient outcomes. Switching the gene off in tumour cells made them far more sensitive to detachment death and weakened several cancer traits. The effect ran through NF-kB signalling, a pathway that helps cells survive, which marks CTSZ as a possible drug target.
Catalog record
| CREATOR | Yiyang Cao, Wei Wu, Yichang Wang, Beichen Zhang, Haoyu Zhou, Mingjing Zhou, Wei Chen, Maode Wang, Jia Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |