High level dynein impairs mitochondrial distribution and differentiation of rhabdomyosarcoma cells
Ting-Ling Ke, Linyi Chen · 2026
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Description
Ting-Ling Ke and Linyi Chen present a study from twenty twenty-six on muscle cancer cells whose mitochondria bunch near the nucleus. The cells come from rhabdomyosarcoma, a rare cancer. They fail to mature into muscle as they should. Their power plants are swollen and stuck in a ring round the core. The team asks what transport flaw drives that bunching.
The cells lack much of a myosin motor that hauls cargo toward the cell edge. They hold too much of a dynein motor that hauls the other way, plus its adaptors. Adding the myosin back partly spread the mitochondria out. Blocking dynein spread them and let both cell lines mature. The work ties transport balance to muscle growth.
Catalog record
| CREATOR | Ting-Ling Ke, Linyi Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |