Single-cell transcriptomic comparison of tubular segment maturation in advanced human in vitro kidney models
Carla Pou Casellas, Fjodor A Yousef Yengej, Carola ME Ammerlaan, Gisela G Slaats, Maarten B Rookmaaker, Marianne C Verhaar, Hans Clevers · 2026
Read Single-cell transcriptomic comparison of tubular segment maturation in advanced human in vitro kidney models by Carla Pou Casellas, Fjodor A Yousef Yengej, Carola ME Ammerlaan, Gisela G Slaats, Maarten B Rookmaaker, Marianne C Verhaar, Hans Clevers (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13223991.txt.
Description
Carla Pou Casellas and co-authors compared lab-grown kidney models in 2026 cell by cell. Such models help teams study how kidneys grow, test drugs, and plan man-made kidneys. The models here are small 3D clumps grown from stem cells or from kidney and urine cells. Each model forms tube parts like those in a real kidney, but how ripe those parts are was not clear.
The team read the gene activity of single cells in each model. They set those reads against real adult and unborn kidney tissue. Each model had its own gene profile, its own mix of cell states, and its own level of ripe markers. The study gives teams a guide for picking the model that fits their question.
Catalog record
| CREATOR | Carla Pou Casellas, Fjodor A Yousef Yengej, Carola ME Ammerlaan, Gisela G Slaats, Maarten B Rookmaaker, Marianne C Verhaar, Hans Clevers |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |