VPS33B regulates MHC class II antigen presentation in dendritic cells to drive CD4 T cell immunity
Kiana Kawarizadeh, Charles N Vallez, Kathrynne A Warrick, Satomi Ando, Margaret M McDaniel, Koichi Araki, Chandrashekhar Pasare · 2026
Read VPS33B regulates MHC class II antigen presentation in dendritic cells to drive CD4 T cell immunity by Kiana Kawarizadeh, Charles N Vallez, Kathrynne A Warrick, Satomi Ando, Margaret M McDaniel, Koichi Araki, Chandrashekhar Pasare (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13223964.txt.
Description
Kiana Kawarizadeh and co-authors describe a 2026 immunology study centred on VPS33B, a protein that helps compartments inside cells fuse. Earlier work linked faulty VPS33B to a rare syndrome affecting joints, kidneys, and bile flow. The new work asks what the protein does in dendritic cells, which show fragments of microbes to other immune cells.
Removing VPS33B from dendritic cells weakened their display of peptides on MHC class II molecules, and CD4 T cell responses fell as a result. Responses that depend on CD4 help also suffered, while direct CD8 priming stayed intact. The cells mainly displayed leftover pieces of the invariant chain, pointing to a loading fault.
Catalog record
| CREATOR | Kiana Kawarizadeh, Charles N Vallez, Kathrynne A Warrick, Satomi Ando, Margaret M McDaniel, Koichi Araki, Chandrashekhar Pasare |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |