Not who we treat, but how we treat: Emphasizing treatment adherence in neuromodulation outcomes
Ryan S D'Souza, David Hao, Salim M Hayek · 2026
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Description
Ryan D'Souza, David Hao, and Salim Hayek argue that how faithfully a treatment is delivered matters as much as which patient gets it, in a 2026 commentary on neuromodulation for chronic pain. They point to a follow-up analysis of the RESET trial, which tested 60-day peripheral nerve stimulation for chronic low back pain. Of 93 patients who finished treatment, 67 met the full protocol and 26 did not.
Patients who got the therapy as designed had about three times the odds of cutting their pain in half at three months. Good delivery meant solid coverage of the painful area and 6 to 12 hours of daily stimulator use. Traits like age, sex, and pain duration showed no such link. The authors urge the field to study delivery and adherence as closely as patient selection.
Catalog record
| CREATOR | Ryan S D'Souza, David Hao, Salim M Hayek |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 10 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |