Amelioration of tic disorder by Jujuboside A via gut microbiota remodeling and intestinal 5-HT signaling
Fei Fan, Bo Wang, Ru Jia, Jing Lyu, Fei Han · 2026
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Description
Fei Fan and colleagues treated tic disorder in rats with a plant compound in 2026. Tic disorder starts in childhood commonly. It is a chronic neuropsychiatric condition. Jujuboside A may ease its symptoms. Mechanisms were unknown before this work. A rat model reproduced the disorder.
Tissue damage eased under the compound. Gut microbe balance shifted favourably too. Helpful bacterial groups grew in share. Less helpful groups declined under treatment. Gut serotonin signalling also changed measurably. A serotonin-making gene switched on more. The gut-brain route looks central here. Clinical translation needs much more work.
Catalog record
| CREATOR | Fei Fan, Bo Wang, Ru Jia, Jing Lyu, Fei Han |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |