Evaluation of tissue-engineered blood vessels as three-dimensional in vitro testing system in cardiovascular research
Diana M. Rojas-González, Frederic Wolf, Nicole Schaaps, Roberta A. Florescu, Carolina Bienzeisler, Rahma Shahin, Celine Brinkmann, Pakhwan Nilcham, Felix Vogt, Stefan Jockenhoevel, Anne Turoni-Glitz, Petra Mela · 2026
Read Evaluation of tissue-engineered blood vessels as three-dimensional in vitro testing system in cardiovascular research by Diana M. Rojas-González, Frederic Wolf, Nicole Schaaps, Roberta A. Florescu, Carolina Bienzeisler, Rahma Shahin, Celine Brinkmann, Pakhwan Nilcham, Felix Vogt, Stefan Jockenhoevel, Anne Turoni-Glitz, Petra Mela (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13223119.txt.
Description
Diana M Rojas-Gonzalez and co-authors test lab-grown blood vessels as a stand-in for human arteries in heart research. Faulty talk between lining cells and muscle cells drives the wall thickening that re-blocks arteries after treatment. Flat cell dishes miss that three-dimensional crosstalk.
Their vessels grow muscle cells in a fibrin gel over a textile mesh, then gain a lining of endothelial cells. Pumps run artery-like flow over them for three weeks. Vessels with thin or patchy lining grew thicker, messier walls. At day seven the team could balloon the vessels and set plain or drug-coated stents, just as in patients. Two weeks later, ballooned vessels showed the wall thickening doctors fear. The model gives drug and device teams a human-like test bed.
Catalog record
| CREATOR | Diana M. Rojas-González, Frederic Wolf, Nicole Schaaps, Roberta A. Florescu, Carolina Bienzeisler, Rahma Shahin, Celine Brinkmann, Pakhwan Nilcham, Felix Vogt, Stefan Jockenhoevel, Anne Turoni-Glitz, Petra Mela |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |