Global perspectives on lupus nephritis: a review of clinical trials and therapeutic innovations
Jiaruo Xu, Yongkang Zhang, Hui Huang, Yemin Cao · 2026
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Description
Jiaruo Xu and co-authors survey two decades of drug trials for lupus nephritis, the kidney attack of lupus. They mined two hundred trials from three global registries. Phase two and three trials are speeding up, and the map of testing is shifting toward Asia and the Pacific.
Targets have widened past B cell depletion. New entries block complement, jam inner cell signals, or reset immunity with engineered cells. Yet full kidney response still stalls near half of patients in key trials, a ceiling the authors flag. Their fixes: gene guided drug choice, faster steroid tapering, and live molecular markers. The review charts a field mid turn toward precision care.
Catalog record
| CREATOR | Jiaruo Xu, Yongkang Zhang, Hui Huang, Yemin Cao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |