A Porphyrinic Covalent Organic Polymer Nanoplatform for Carborane Delivery and Multifunctional Imaging-Guided Boron Neutron Capture Therapy of Breast Cancer
Jing Ren, Tingran Wang, Changmin Zuo, Ruiping Zhang, Liping Li · 2026
Read A Porphyrinic Covalent Organic Polymer Nanoplatform for Carborane Delivery and Multifunctional Imaging-Guided Boron Neutron Capture Therapy of Breast Cancer by Jing Ren, Tingran Wang, Changmin Zuo, Ruiping Zhang, Liping Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13222609.txt.
Description
Jing Ren and co-authors build a nanoplatform that delivers boron into breast tumors for neutron capture therapy, in a 2026 study. The therapy needs boron loaded into tumors and traceable during treatment. Their polymer particles carry a boron-rich compound called carborane, use porphyrin units that fluoresce, and wear a stabilizing surface coat.
The particles held a high boron share and stayed stable in suspension. Breast cancer cells took them up efficiently and kept them. In mice, fluorescence imaging confirmed tumor localization after injection. Combined with thermal neutron irradiation, the platform suppressed tumor growth by about seventy-three percent against controls, without significant body-wide toxicity on tissue checks. Imaging and therapy arrive in one package.
Catalog record
| CREATOR | Jing Ren, Tingran Wang, Changmin Zuo, Ruiping Zhang, Liping Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |