Maternal, Fetal, and Neonatal Outcomes of Additional Dihydroartemisinin-Piperaquine to Trimethoprim-Sulfamethoxazole in Intermittent Preventive Treatment for Malaria in HIV-Positive Pregnancies: A Systematic Review and Meta-Analysis
Vycke Yunivita, Amanda Jessie Maharani, Cheryl Antoinette Bernadus, Eva Ianty Julwana Sinaga, Evita Rahel Simanjuntak · 2026
Read Maternal, Fetal, and Neonatal Outcomes of Additional Dihydroartemisinin-Piperaquine to Trimethoprim-Sulfamethoxazole in Intermittent Preventive Treatment for Malaria in HIV-Positive Pregnancies: A Systematic Review and Meta-Analysis by Vycke Yunivita, Amanda Jessie Maharani, Cheryl Antoinette Bernadus, Eva Ianty Julwana Sinaga, Evita Rahel Simanjuntak (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13222561.txt.
Description
Vycke Yunivita and co-authors pool trials on adding an antimalarial pair to standard prevention in HIV-positive pregnancy, in a 2026 systematic review and meta-analysis. Three studies with 1,353 participants met the criteria after screening nearly four hundred records. Mothers received sulfamethoxazole-trimethoprim with or without dihydroartemisinin-piperaquine given three times.
Adding the antimalarial showed a non-significant trend toward fewer malaria infections in mothers and placentas. Maternal side effects overall were significantly fewer in the added-drug group, including stomach and gut complaints. Fetal events and birth outcomes, such as low birth weight and early delivery, did not differ significantly. The combination appears safe on these data, with malaria benefit still unproven.
Catalog record
| CREATOR | Vycke Yunivita, Amanda Jessie Maharani, Cheryl Antoinette Bernadus, Eva Ianty Julwana Sinaga, Evita Rahel Simanjuntak |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |