HighRes_Builder: improved access and modeling of noncanonical residues for protein structure prediction
Yanchao Han, Jianfeng Mei, Gaoshuai Li, Enkang Dai, Hanlei Lu, Chengyun Zhang, Yanlu Zhang, Chenshui Lin, Chuanlong Zeng, Hongliang Duan, Xudong Wang · 2026
Read HighRes_Builder: improved access and modeling of noncanonical residues for protein structure prediction by Yanchao Han, Jianfeng Mei, Gaoshuai Li, Enkang Dai, Hanlei Lu, Chengyun Zhang, Yanlu Zhang, Chenshui Lin, Chuanlong Zeng, Hongliang Duan, Xudong Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13222519.txt.
Description
Yanchao Han and co-authors introduce a software tool that helps predict the shapes of proteins built with unusual building blocks, in a 2026 paper. Standard prediction tools rely on a dictionary of known chemical parts, but that dictionary lacks many modified amino acids found in useful peptides and drugs. Their tool, HighRes_Builder, searches for and builds these missing parts on its own.
The team used the tool to model more than 3,000 unusual residues with the AlphaFold3 system, and every one was accepted. Most of the predicted shapes passed strict checks on their geometry. They also modeled real drug peptides, one straight and two ring-shaped, bound to their target proteins. The results show details of how these drugs grip their targets.
Catalog record
| CREATOR | Yanchao Han, Jianfeng Mei, Gaoshuai Li, Enkang Dai, Hanlei Lu, Chengyun Zhang, Yanlu Zhang, Chenshui Lin, Chuanlong Zeng, Hongliang Duan, Xudong Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |