Innovative AC Electrospinning and Characterization of Nanofibers Comprised of Polyvinyl Alcohol and Dacarbazine for Solid State Drug Delivery of Cancer Therapeutic
Rachel E Murphy, Yongzhe Yan, Jadyn Parker, Subhayu Sen, W Anthony Brayer, Haibin Ning · 2026
Read Innovative AC Electrospinning and Characterization of Nanofibers Comprised of Polyvinyl Alcohol and Dacarbazine for Solid State Drug Delivery of Cancer Therapeutic by Rachel E Murphy, Yongzhe Yan, Jadyn Parker, Subhayu Sen, W Anthony Brayer, Haibin Ning (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13222246.txt.
Description
Rachel E Murphy and co-authors spin nanofibers carrying the chemotherapy drug dacarbazine, in a 2026 materials study using alternating-current electrospinning. The drug fights tumors yet breaks down quickly, lasts briefly in the body, and cannot cross into the brain. Four blends of polyvinyl alcohol and drug were spun at very high production rates.
Microscopy and spectroscopy showed the drug dispersed well inside the fibers without losing its identity. Fibers kept favorable shapes across the blend ratios, and the solid form stabilized the drug. Loading efficiency and release were measured with light-based assays. The platform could support local delivery of the drug, with release behavior and stability studies still ahead.
Catalog record
| CREATOR | Rachel E Murphy, Yongzhe Yan, Jadyn Parker, Subhayu Sen, W Anthony Brayer, Haibin Ning |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |