Blue Light Induces Retinal Ganglion Cell Damage by Stimulating Drp1-Dependent Mitochondrial Fission and Activating NF-κB/NOX4 Axis
Xin-Hao Han, Tao Wang, Gui-Feng Sun, Xin Xie, Kun Zhang, Xiao-Yu Wang, Zhen Zhang, Xing Wang, Xin-Hui Qu, Xiao-Jian Han · 2026
Read Blue Light Induces Retinal Ganglion Cell Damage by Stimulating Drp1-Dependent Mitochondrial Fission and Activating NF-κB/NOX4 Axis by Xin-Hao Han, Tao Wang, Gui-Feng Sun, Xin Xie, Kun Zhang, Xiao-Yu Wang, Zhen Zhang, Xing Wang, Xin-Hui Qu, Xiao-Jian Han (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13221732.txt.
Description
Blue light from screens and lamps can harm the nerve cells that carry sight from eye to brain. Xin-Hao Han and co-authors trace that harm in a 2026 study of retinal ganglion cells. They test cells in dishes and in living eyes, and hunt the chain of events that ends in cell death.
Blue light drove the cells' power units to split apart, the team found. That split woke a stress path that raised a harm enzyme and flooded the units with reactive oxygen. Blocking the split or the enzyme curbed the damage. Blocking both restored the power units and cut cell death most. The chain offers drug targets for light-linked eye harm.
Catalog record
| CREATOR | Xin-Hao Han, Tao Wang, Gui-Feng Sun, Xin Xie, Kun Zhang, Xiao-Yu Wang, Zhen Zhang, Xing Wang, Xin-Hui Qu, Xiao-Jian Han |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |