Drosophila pan-glial inducible Gal4 line alters baseline sleep
Seanna E Kelly, Keisuke Fukumura, Daridh Mao, Vinithra Kathirvel, Shorbon Mowla, Annika F Barber · 2026
Read Drosophila pan-glial inducible Gal4 line alters baseline sleep by Seanna E Kelly, Keisuke Fukumura, Daridh Mao, Vinithra Kathirvel, Shorbon Mowla, Annika F Barber (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13221703.txt.
Description
Seanna Kelly, Keisuke Fukumura, Daridh Mao, Vinithra Kathirvel, Shorbon Mowla, and Annika Barber warn that a common fruit fly tool itself changes sleep in work dated two thousand twenty-six. The GeneSwitch system turns genes on with a drug and is widely used in fly brain studies. One line targets the glial support cells of the brain.
That line, on its own, cut baseline sleep by a large amount, day and night, when the switch drug was present. The effect showed even with no target gene attached to the switch. Small true effects of a studied gene could thus hide under the tool's own impact. The authors urge study designs that can spot such shifts.
Catalog record
| CREATOR | Seanna E Kelly, Keisuke Fukumura, Daridh Mao, Vinithra Kathirvel, Shorbon Mowla, Annika F Barber |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 13 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |