High molecular weight insoluble parkin in the substantia nigra of patients with idiopathic Parkinson’s disease
Cyntia Tremblay, Laura Pshevorskiy, Rosalie J. Cottez, Hélèna L. Denis, Vincent Emond, Marc Morissette, Ali H. Rajput, Thérèse Di Paolo, Alex Rajput, Frédéric Calon · 2026
Read High molecular weight insoluble parkin in the substantia nigra of patients with idiopathic Parkinson’s disease by Cyntia Tremblay, Laura Pshevorskiy, Rosalie J. Cottez, Hélèna L. Denis, Vincent Emond, Marc Morissette, Ali H. Rajput, Thérèse Di Paolo, Alex Rajput, Frédéric Calon (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13221466.txt.
Description
Cyntia Tremblay and co-authors find clumped parkin protein in Parkinson brains in this 2026 paper. Parkin faults cause a young-onset form of the disease, but its role in the common form was unclear. The substantia nigra loses dopamine cells in both kinds.
The team compared brain tissue from 24 patients and 21 controls. Dopamine in one target region had fallen by ninety-six percent in patients. A marked form of alpha-synuclein was twenty-three times higher in the substantia nigra. There, an insoluble heavy form of parkin rose by about half, while the normal light form dropped. Levels tracked synuclein load and dopamine loss, most in patients with treatment-linked jerky movements.
Catalog record
| CREATOR | Cyntia Tremblay, Laura Pshevorskiy, Rosalie J. Cottez, Hélèna L. Denis, Vincent Emond, Marc Morissette, Ali H. Rajput, Thérèse Di Paolo, Alex Rajput, Frédéric Calon |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |