The miR4261/PAMM axis in multiple myeloma promotes bone resorption
Jiangxia Cui, Sicheng Bian, Zhuanghui Hao, Xialin Zhang, Chen Zhang, Yun Zhao, Xiuyan Zhang, Hongwei Wang · 2026
Read The miR4261/PAMM axis in multiple myeloma promotes bone resorption by Jiangxia Cui, Sicheng Bian, Zhuanghui Hao, Xialin Zhang, Chen Zhang, Yun Zhao, Xiuyan Zhang, Hongwei Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13221460.txt.
Description
Jiangxia Cui and colleagues trace a molecular axis driving bone loss in multiple myeloma, in a 2026 laboratory study. Myeloma bone disease affects most patients with this blood cancer, as bone-eating cells grow overactive. The team focused on a small RNA, miR4261, and a protein called PAMM found in patient samples and cell cultures.
High miR4261 levels matched low PAMM levels in patients with bone disease. Tests confirmed the RNA binds and suppresses PAMM, and lowering PAMM sped formation of bone-eating cells. Gene patterns shifted the same way. Blocking the axis at either point might slow the bone destruction that disables many myeloma patients.
Catalog record
| CREATOR | Jiangxia Cui, Sicheng Bian, Zhuanghui Hao, Xialin Zhang, Chen Zhang, Yun Zhao, Xiuyan Zhang, Hongwei Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |