Oncofertility in the Age of HER2 Blockade, Immunotherapy, PARP inhibitors, CDK4/6 inhibitors and Endocrine Treatment: Unanswered Questions in Breast Cancer
Karolina Weiner-Gorzel, Lynda McSorley, Janice M Walshe · 2026
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Description
Karolina Weiner-Gorzel, Lynda McSorley, and Janice M Walshe review unanswered fertility questions in modern breast cancer care, in a 2026 opinion piece. Survival for younger patients keeps improving, yet worries about fertility and pregnancy safety can lead some to refuse or stop treatment. The authors argue counseling belongs in planning from diagnosis onward.
Chemotherapy remains the main threat to ovarian function, and temporary ovarian suppression deserves routine consideration. Hormone therapy does not permanently damage ovaries, though its long course needs personal pregnancy planning. For newer drug classes, human fertility data are largely absent, so the authors urge caution, preservation before treatment, and honest discussion of uncertainty.
Catalog record
| CREATOR | Karolina Weiner-Gorzel, Lynda McSorley, Janice M Walshe |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |